Cytochrome P-450 CYP21
《英文msh詞典》Cytochrome P-450 CYP21
[同義詞] Cytochrome P-450 CYP21
[主題詞] Steroid 21-Hydroxylase
[英文釋義] An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP21 gene,converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA,CONGENITAL).